List of publications


Juncker T., Richert L., Masson M., Zuber G., Chatton B., Donzeau M. (2024). Tracing endogenous proteins in living cells through electrotransfer of mRNA encoding chromobodies.Biotechnol J 2024, 19 (2), e2300548. DOI:10.1002/biot.202300548

Wagner P., Gulea M., Girard N. (2024). Hydroformylation of Alkynyl Sulfides: A Stereo- and Regioselective Route to α-Sulfenyl Acroleins. Adv. Synth. Catal. 2024, 366. DOI:10.1002/adsc.202301349

Frisch E., Dussouillez C., McCartin C., Blumberger J., Humbert C., Lebeau L., Frisch B., Heurtault B., Kichler A., Fournel S. (2024). Reduction of Pro-inflammatory Markers in RAW264.7 Macrophages by Polyethylenimines.Macromolecular Bioscience2024 Feb 28:e2300492. DOI:10.1002/mabi.202300492

Dussouillez C., Lointier M., Sebane M.K., Fournel S., Bechinger B., Kichler A. (2024). N-terminal modification of an LAH4 derived peptide increases mRNA delivery in the presence of serum.Journal of Peptide Science, 2024, sous presse


Puja H., Mislin G., Rigouin C. (2023). Engineering Siderophore Biosynthesis and Regulation Pathways to Increase Diversity and Availability
Biomolecules;13(6):959. doi: 10.3390/biom13060959

Olshvang E., Fritsch S., Scholtyssek O.C., Schalk I., Metzler-Nolte N. (2023). Vectorization via Siderophores Increases Antibacterial Activity of K(RW)3 Peptides against Pseudomonas aeruginosa.Chemistry. 2023;29(50):e202300364.DOI:10.1002/chem.202300364
Hubert T., Madec M., Schalk I. (2023). Experimental and computational methods to highlight behavioural variations in TonB-dependent transporter expression in Pseudomonas aeruginosa versus siderophore concentration. Sci Rep. 2023;13(1):20015. DOI:10.1038/s41598-023-46585-z

Anne F., Gwenaëlle G., Isabelle S., Pierre F. (2023). Improved engineering of Pseudomonas aeruginosa to study the adaptation of pyoverdine production under intra- or inter- specific bacterial competition.J Microbiol Methods 210:106753. DOI:10.1016/j.mimet.2023.106753

Groysbeck N., Haeberle A.M., Ory S., Hanss V., Eltsov M., Schultz P., Zuber G. (2023). 1.4 nm gold anoparticle-antibody conjugates for in situ immunolabelling after transduction into living human cells.Comptes Rendus Chimie2023, 26, 1–14 DOI:10.5802/crchim.251

Groysbeck N., Hanss V., Donzeau M., Strub J.M., Cianferani S., Spehner D., Bahri M., Ersen O., Eltsov M., Schultz P., Zuber G. Bioactivated and PEG-Protected Circa 2 nm Gold Nanoparticles for in Cell Labelling and Cryo-Electron Microscopy.Small Methods 2023, e2300098. DOI:10.1002/smtd.202300098

Maujean T., Wagner P., Valencia C., Riché S., Iturrioz X., Villa P., Girard N., Karpenko J., Gulea M., Bonnet D. (2023). Rapid and Highly Selective Fluorescent Labeling of Peptides via a Thia-Diels-Alder Cycloaddition: Application to Apelin.
Bioconjugate Chem. 2023, 34, 1, 162–168. DOI: 10.1021/acs.bioconjchem.2c00500
Maujean T., Marchand P., Wagner P., Riché S., Boisson F., Girard N., Karpenko J., Bonnet D., Gulea M. (2023). Catalyst-free thia-Diels-Alder click reaction for the labeling of peptides for imaging applications.Phosphorus, Sulfur Silicon Relat. 2023, special issue 29th International Symposium on Organic Chemistry of Sulfur (ISOCS29).DOI:10.1080/10426507.2023.2165659

Lopes A. B., Choury M., Wagner P., Gulea M. (2023). Synthesis of new N/S-containing compounds by Pd-catalyzed tandem reactions. Phosphorus, Sulfur Silicon Relat. 2023, special issue 29th International Symposium on Organic Chemistry of Sulfur (ISOCS29). DOI: 10.1080/10426507.2022.2150857

Brion A., Chaud J., Léonard J., Bolze F., Chassaing S., Frisch B., Heurtault B., Kichler A., Specht A. (2023). Red Light-Responsive Upconverting Nanoparticles for Quantitative and Controlled Release of a Coumarin-Based Prodrug. Advanced Healthcare Materials. 12(2):e2201474. DOI: 10.1002/adhm.202201474

Brion A., Chaud J., Klimezak M., Bolze F., Ohlmann L., Léonard J., Chassaing S., Frisch B., Kichler A., Heurtault B., Specht A. (2023). Photoactivatable Liposomes for Blue to Deep Red Light-Activated Surface Drug Release: Application to Controlled Delivery of the Antitumoral Drug Melphalan. Bioconjug Chem. 34(7):1304-1315. DOI:10.1021/acs.bioconjchem.3c00197.

McCartin C., Blumberger J., Dussouillez C., Fernandez de Larrinoaa P., Dontenwill M., Herold-Mende C., Heurtault B., Bellemin-Laponnaz S., Fournel S., Kichler A. (2023). Evaluation of the cytotoxicity of cationic polymers on glioblastoma cancer stem cells. Journal of Functional Biomaterials, 2023, 14(1), 17. DOI:10.3390/jfb14010017

Conrad O., Burgy M., Foppolo S., Jehl A., Thiéry A., Guihard S., Vauchelles R., Jung Alain C., Mourtada J., Macabre C., Ledrappier S, Chenard M.P., Onea M.A., Danic A., Dourlhes T., Thibault C., Schultz P., Dontenwill M. and Martin S. (2023). Tumor-Suppressive and Immunomodulating Activity of miR-30a-3p and miR-30e-3p in HNSCC Cells and Tumoroids. Int. J. Mol. Sci. 2023, 24(13), 11178. DOI:10.3390/ijms241311178

Bernhard C., Reita D, Martin S., Entz-Werle N. and Dontenwill M. (2023). Glioblastoma Metabolism: Insights and Therapeutic Strategies. Int. J. Mol. Sci. 2023, 24(11), 9137. DOI:10.3390/ijms24119137

Jehl A., Conrad O., Burgy M., Foppolo S., Vauchelles R., Ronzani C., Etienne-Selloum N., Chenard M.P., Danic A., Dourlhes T., Thibault C., Schultz P., Dontenwill M. and Martin S. (2023) Blocking EREG/GPX4 Sensitizes Head and Neck Cancer to Cetuximab through Ferroptosis Induction. Cells 2023, 12(5), 733. DOI:10.3390/cells12050733

Petit B. E., Jobelius H., Bianchino G. I., Guérin M.,Borel F., Chaignon P., Seemann M. (2023). Synthesis and kinetic evaluation of analogs of (E)-4-amino-3-methylbut-2-en-1-yl diphosphate, a potent inhibitor of the IspH metalloenzyme. C.R. Chimie,numéro special Chemical Biology (Online first (2023), pp. 1-14). DOI:10.5802/crchim.254


Fritsch S., Gasser V., Peukert C., Pinkert L., Kuhn L., Perraud Q., Normant V., Brönstrup M., Schalk I.J. (2022). Uptake Mechanisms and Regulatory Responses to MECAM- and DOTAM-Based Artificial Siderophores and Their Antibiotic Conjugates in Pseudomonas aeruginosa
ACS Infect Dis. 2022;8(6):1134-1146. DOI:10.1021/acsinfecdis.2c00049

Khaddour W., Dumas N., Dadouche F., Madec M. and Uhring. (2022). A low-cost high throughput microfluidics system for multi-thousand droplets W. per second sorting based on time resolved fluorescence measurement. Symposium on Design, Test, Integration and Packaging of MEMS/MOEMS (DTIP), 1-4. DOI:10.1109/DTIP56576.2022.9911730

Van Wesemael C., Brach N., Gulea M., Blond G. (2022). Gold(I)-Catalyzed Carbothiolation via Rearrangement of S-Propargyl Group: An Access to 3-Allenyl or 3-Indenyl Benzo[b]thiophenes. Adv. Synth. Catal. 364:4141–4145 (selected VIP). DOI:10.1002/adsc.202201000.

Moynié L., Hoegy F., Milenkovic S., Munier M., Paulen A., Gasser V., Faucon A., Zill N., Naismith J.H., Ceccarelli M., Schalk I.J., Mislin G.L.A. (2022). Hijacking of the enterobactin pathway by a synthetic catechol vector designed for oxazolidinone antibiotic delivery in Pseudomonas aeruginosa. ACS Infect. Dis. 2022, 8, 1894 (Cover page). DOI:10.1021/acsinfecdis.2c00202.

Normant V., Kuhn L., Munier M., Hammann P., Mislin, G.L.A., Schalk I.J. (2022). How the Presence of Hemin Affects the Expression of the Different Iron Uptake Pathways in Pseudomonas aeruginosa Cells.ACS Infect. Dis. 2022, 8, 183 (Cover page). DOI:10.1021/acsinfecdis.1c00525.

Brion A., Chaud J., Léonard J., Bolze F., Chassaing S., Frisch B., Heurtault B., Kichler A., Specht A. (2022). Red Light-Responsive Upconverting Nanoparticles for Quantitative and Controlled Release of a Coumarin-Based Prodrug. Advanced Healthcare Materials 12:e2201474.DOI:10.1002/adhm.202201474.

McCartin C., Dussouillez C., Bernhard C., Mathieu E., Blumberger J., Dontenwill M., Herold-Mende C., Idbaih A., Lavalle P., Bellemin-Laponnaz S., Kichler A., Fournel S. (2022). Polyethylenimine, an autophagy inducing platinum-carbene-based drug carrier with potent toxicity towards glioblastoma cancer stem cells. Cancers 14(20):5057. DOI:10.3390/cancers14205057.

McCartin C., Mathieu E., Dontenwill M., Herold-Mende C., Idbaihf A., Bonfigliog A., Mauro M., Fournel S., Kichler A. (2022). An N-heterocyclic carbene iridium(III) complex as a potent anti-cancer stem cell therapeutic.Chemico-Biological Interactions 367:110167. DOI:10.1016/j.cbi.2022.110167.

Moeglin E., Barret L., Chatton B., Donzeau M. (2022).Modular Site-Specific Conjugation of Nanobodies Using Two Co-Associating Tags.Int. J. Molecular Sciences23(22):14405. DOI:10.3390/ijms232214405.

Arezki Y., Delalande F., Schaeffer C., Rapp M., Lebeau L., Pons F., Ronzani C. (2022). Surface charge influences protein corona, cell uptake and biological effects of carbon dots.Nanoscale. 14, 14695. DOI:10.1039/D2NR03611H.

Maujean T., Marchand P., Wagner P., Girard N., Riché S., Boisson F., Bonnet D., Gulea M. (2022). Hetero-Diels-Alder Click Reaction of Dithioesters for a Catalyst-Free Indirect 18F-Radiolabelling of Peptides. Chem. Commun. 2022. DOI:10.1039/D2CC04148K.

Choury M., Wagner P., Rognan C., Blond G., Gulea M. (2022). Access to 1,4-Thiazepanes via Gold-Catalyzed 7-exo-dig Thioallylation and their Cycloisomerization to Bicyclic [4.3.1] Bridgehead-Olefinic Systems. Adv. Synth. Catal. 2022 (selected VIP) DOI:10.1002/adsc.202200660.

Arezki Y., Rapp M., Lebeau L., Ronzani C., Pons F. (2022). Cationic Carbon Nanoparticles Induce Inflammasome-Dependent Pyroptosis in Macrophages via Lysosomal Dysfunction.Front Toxicol. 4:925399. DOI:10.3389/ftox.2022.925399.

Sonntag T., Rapp M., Didier P., Lebeau L., Pons F., Casset A. (2022). Mucus producing epithelial models for investigating the activity of gene delivery systems in the lung. Int. J. Pharm. 614:121423. DOI:10.1016/j.ijpharm.2021.121423.

Sani S., Pallaoro N., Messe M., Bernhard C., Etienne-Selloum N., Kessler H., Marinelli L., Entz-Werle N., Foppolo S., Martin S., Reita D., Dontenwill M. (2022). Temozolomide-Acquired Resistance Is Associated with Modulation of the Integrin Repertoire in Glioblastoma, Impact of α5β1 Integrin. Cancers (Basel). 12;14(2):369. DOI:10.3390/cancers14020369.

Ali S., Dussouillez C., Padilla B., Frisch B., Mason A.J., Kichler A. (2022). Design of a new cell penetrating peptide for DNA, siRNA and mRNA deliveryJ Gene Med. 24(3):e3401. DOI:10.1002/jgm.3401.

Herrscher V., Witjaksono C., Buchotte M., Ferret C., Massicot F., Vasse J.L., Borel F., Behr J.B., Seemann M. (2022). Irreversible inhibition of IspG, a target for the development of new antimicrobials, by a 2-vinyl analogue of its MEcPP substrate. Chem. Eur. J. DOI:10.1002/chem.202200241.

Jobelius H., Bianchino G.I., Borel F., Chaignon P., Seemann M. (2022). The Reductive Dehydroxylation Catalyzed by IspH, a Source of Inspiration for the Development of Novel Anti-Infectives. Molecules 27(3), 708. DOI:10.3390/molecules27030708.

Aline L.Faucon, Françoise Hoegy, Noémie Werle, Christophe Gourlaouen, Gaëtan L.A. Mislin (2022). Dipyridylamine-acetamide (Dpaa): A primary amine protecting group orthogonally cleavable under acidic conditions in the presence of t-butyloxycarbonyl (Boc) and t-butylester. Tet. Lett., 96, 153758. DOI:10.1016/j.tetlet.2022.153758.

Roméric Galéa, Gaëlle Blond (2022). Gold(I)-Catalyzed Domino Reaction: An Access to Furooxepines. Adv. Synth. Catal. 364, 1532. DOI:10.1002/adsc.202200019.


Kouijzer, J.J.P. ; Lattwein, K.R.; Beekers, I. ; Langeveld, S.A.G. ; Leon-Grooters, M. ; Strub, J.-M. ; Oliva, E. ; Mislin, G.L.A. ; de Jong, N. ; van der Steen, A.F.W. ; Klibanov, A.L. ; van Wamel, W.J.B. ; Kooiman, K. (2021). Vancomycin-decorated microbubbles as a theranostic agent for Staphylococcus aureus biofilm. Int. J. Pharm. 2021, 121154.

Dietsch F., Nominé Y., Stoessel A., Kostmann C., Bonhoure A., Chatton B., Donzeau M. (2021). Small p53 derived peptide suitable for robust nanobodies dimerization. Journal of Immunological 498:112144. DOI:10.1016/j.jim.2021.113144

Arezki Y., Cornacchia J., Rapp M., Lebeau L., Pons F., Ronzani C. (2021). A co-culture model of the human respiratory tract to discriminate the toxicological profile of cationic nanoparticles according to their surface charge density. Toxics 9:210. DOI:10.3390/toxics9090210

Mauger M., Ferreri C., Chatgilialoglu C., Seemann M. (2021). The bacterial protective armor against stress: The cis-trans isomerase of unsaturated fatty acids, a cytochrome-c type enzyme. J. Inorg. Biochem. 224: 111564. DOI:10.1016/j.jinorgbio.2021.111564

Tetard A., Foley S., Mislin G.L.A., Brunel J.M., Oliva E., Torrealba Anzola F., Zedet A., Cardey B., Pellequer Y., Ramseyer C., Plésiat P., Llanes C. (2021). Negative impact of citral on cusceptibility of Pseudomonas aeruginosa to antibiotics. Front. Microbiol 12:709838. DOI:10.3389/fmicb.2021.709838

Michaut M., Steffen A., Contreras J.-M., Morice C., Schalk I.J., Plésiat P., Mislin G.L.A. (2021). 1,2,3-Triazole-gold(I)-triethylposphine derivatives active against resistant Gram-positive pathogens. Bioorg. Med. Chem. Lett. 40:127879. DOI:10.1016/j.bmcl.2021.127879

Perraud Q., Kuhn L., Fritsch S., Graulier G., Gasser V., Normant V., Hammann P., Schalk I.J. (2021). Opportunistic use of catecholamine neurotransmitters as siderophores to access iron by Pseudomonas aeruginosa. Environ. Microbiol.  24(2):878-893. DOI:10.1111/1462-2920.15372

Gasser V., Kuhn L., Hubert T., Aussel L., Hammann P., Schalk I.J. (2021). The esterase PfeE, the Achilles’ heel in the battle for iron between P. aeruginosa and E. coli. Int. J. Mol. Sci. 22(6):2814. DOI:10.3390/ijms22062814

Miethke M., Pieroni M., Weber T., Brönstrup M., Hammann P., Halby L., Arimondo P., Glaser P., Aigle B., Bode H., Moreira R., Li Y., Luzhetskyy A., Medema M., Pernodet J.-L., Stadler M., Tormo J., Genilloud O., Truman A., Weissman K., Takano E., Sabatini S., Stegmann E., Brötz-Oesterhelt H., Wohlleben W., Seemann M., Empting M., Hirsch A., Loretz B., Lehr C.-M., Titz A., Herrmann J., Jaeger T., Alt S., Hesterkamp T., Winterhalter M., Schiefer A., Pfarr K., Hoerauf A., Graz H., Graz M., Lindvall M., Ramurthy S., Karlén A., van Dongen M., Petković H., Keller A., Peyrane F., Donadio S., Fraisse L., Piddock L., Gilbert I., Moser H., Müller R. (2021). Towards the sustainable discovery and development of new antibiotics. Nat Rev Chem 5(10):726-749. DOI:10.1038/s41570-021-00313-1

Choury M., Blond G., Gulea M. (2021). A synthetic route to benzothiazocines with two or three carbon stereocenters via copper‐catalyzed intramolecular Narylation. Eur. J. Org. Chem. 2021:2203-2211. DOI:10.1002/ejoc.202100305

Mazzoleni M., Zimmermann-Meisse G., Smirnova A., Tarassov I., Prévost G. (2021). Staphylococcus aureus Panton-Valentine Leukocidin triggers an alternative NETosis process targeting mitochondria. FASEB J. 35:e21167. DOI:10.1096/fj.201902981R

Le Guen C., Dussouillez C., Kichler A., Chan-Seng D. (2021). Insertion of hydrophobic spacers on dodecalysines as potential transfection enhancers. Eur. Polym. J. 157:110654. DOI:10.1016/j.eurpolymj.2021.110654

Spanedda M.V., Bourel-Bonnet L.(2021). Cyclic anhydrides as powerful tools for bioconjugation and smart delivery. Bioconjugate Chem. 32:482-496. DOI:10.1021/acs.bioconjchem.1c00023

Pozza M.D., Orvain C., Brustolin L., Pettenuzzo N., Nardon C., Gaiddon C., Fregona D. (2021). Gold(III) to ruthenium(III) metal exchange in dithiocarbamato complexes tunes their biological mode of action for cytotoxicity in cancer cellsMolecules 26:4073. DOI:10.3390/molecules26134073

Blanchet A., Bourgmayer A., Kurtz J.-E., Mellitzer G., and Gaiddon C. (2021). Isoforms of the p53 family and gastric cancer: a ménage à trois for an unfinished affair. Cancers 13:916. DOI:10.3390/cancers13040916

Gaiddon C., Gross I., Meng X., Sidhoum M, Mellitzer G, Romain B, Delhorme J.B., Venkatasamy A., Jung A., Pfeffer M. (2021). Bypassing the resistance mechanisms of the tumor ecosystem by targeting the endoplasmic reticulum stress pathway using ruthenium-and osmium-based organometallic compounds: An exciting long-term collaboration with Dr. Michel Pfeffer. Molecules 26(17):5386. DOI:10.3390/molecules26175386

Mueller C., Gaiddon C., Venkatasamy A. (2021). Current clinical and pre-clinical imaging approaches to study the cancer-associated immune system. Frontier Immunol. 12:716860. DOI:10.3389/fimmu.2021.716860

El Omar R., Julien E., Biasch K., Guffroy B., Lioure B., Vallat L., Gross I., Domon-Dell C., Lanza F., Gachet C., Negroni M., Freund J.-N., Tavian M. (2021). CDX2 regulates ACE expression in blood development and leukemia cells. Blood Adv. 5(7):2012-2016. DOI:10.1182/bloodadvances.2020003563

Dahlet T. , Truss M., Frede U., Al Adhami H., Bardet A.F., Dumas M., Vallet J., Chicher J., Hammann P., Kottnik S., Hansen P., Luz U., Alvarez G., Auclair G., Hecht J., Robinson P.N., Hagemeier C., Weber M. (2021). E2F6 initiates stable epigenetic silencing of germline genes during embryonic development. Nat. Commun. 12:3582. DOI:10.1038/s41467-021-23596-w

Groysbeck N., Donzeau M., Stoessel A., Haeberlé A.M., Ory S., Spehner D., Schultz P., Ersen O., Bahri M., Ihiawakrim D. and Zuber G. (2021). Gold labelling of Green Fluorescent Protein (GFP)-tag inside cells using recombinant nanobodies conjugated to 2.4 nm thiolate-coated gold nanoparticules. Nanoscale Adv. 3:6940-6948. DOI:10.1039/D1NA00256B


Manko H., Normant V., Perraud Q., Steffan T., Gasser V., Boutant E., Réal É., Schalk I.J., Mély Y., Godet J. (2020). FLIM-FRET Measurements of protein-protein interactions in live bacteria.J. Vis. Exp. 2020, 162. DOI:10.3791/61602

Maujean T., Chataigner I., Girard N., Gulea M., Bonnet D. (2020). Endocyclic enamides derived from aza-diketopiperazines as olefin partners in Povarov reaction: An access to tetracyclic N-heterocycles. Eur. J. Org. Chem. 2020:7385–7395. DOI:10.1002/ejoc.202001339

Olivares E., Tasse J., Badel-Berchoux S., Provot C., Prévost G., Bernardi T. (2020). Clinical Biofilm Ring Test® reveals the potential role of β-lactams in the induction of biofilm formation by P. aeruginosa in cystic fibrosis patients. Pathogens 9:1065. DOI:10.3390/pathogens9121065

Duvergé A., Negroni M. (2020). Pseudotyping lentiviral vectors: When the Clothes Make the Virus. Viruses 12:1311. DOI:10.3390/v12111311

Miller J., Gaiddon C., Storr T. (2020). A balancing act: Using small molecules for therapeutic intervention of the p53 pathway in cancer. Chem. Soc. Rev. 49:6995-7014. DOI:10.1039/d0cs00163e